# nullary MCP server

Negative results intelligence for drug discovery — query measured failures via MCP.

## Links
- Registry page: https://www.getdrio.com/mcp/ai-nullary-nullary
- Repository: https://github.com/nullary-ai/nullary

## Install
- Endpoint: https://mcp.nullary.ai/mcp
- Auth: Not captured

## Setup notes
- Remote endpoint: https://mcp.nullary.ai/mcp

## Tools
- search_inactive_compounds - Inactive small-molecule compound-target pairs. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_selectivity - Small molecules that failed selectivity. Endpoint: https://mcp.nullary.ai/mcp
- search_admet_failures - Small-molecule ADMET failures. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_guides - Failed/ineffective CRISPR guides. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_essentiality_screens - Non-dependency / failed essentiality screens. Endpoint: https://mcp.nullary.ai/mcp
- search_ancestry_specific_failures - Ancestry-specific CRISPR failures. Endpoint: https://mcp.nullary.ai/mcp
- search_developability_failures - Antibody developability failures. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_clinical_antibodies - Discontinued/terminated clinical antibodies. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_peptide_therapeutics - Failed peptide therapeutics. Endpoint: https://mcp.nullary.ai/mcp
- search_peptide_stability_issues - Peptide stability/half-life failures. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_protacs - PROTACs that failed degradation/ternary/permeability. Endpoint: https://mcp.nullary.ai/mcp
- search_protac_e3_issues - PROTAC E3-ligase recruitment / ternary failures. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_oligonucleotides - ASOs/siRNAs that failed engagement/developability. Endpoint: https://mcp.nullary.ai/mcp
- search_oligo_delivery_failures - Oligonucleotide delivery failures. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_vaccines - Failed/terminated vaccines (by pathogen/indication). Endpoint: https://mcp.nullary.ai/mcp
- search_vaccine_immunogenicity_failures - Failed vaccine immunogen designs. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_adcs - ADCs that failed at any stage. Endpoint: https://mcp.nullary.ai/mcp
- search_adc_linker_failures - ADC failures attributed to linker chemistry. Endpoint: https://mcp.nullary.ai/mcp
- search_failed_bispecifics - Bispecifics that failed at any stage. Endpoint: https://mcp.nullary.ai/mcp
- search_bispecific_format_failures - Bispecific format/engineering failures. Endpoint: https://mcp.nullary.ai/mcp
- search_admet_failures_all_modalities - ADMET failures across ALL modalities. Endpoint: https://mcp.nullary.ai/mcp
- search_drug_drug_interaction_failures - Drug-drug interaction failures. Endpoint: https://mcp.nullary.ai/mcp
- search_mechanism_failures - Approaches that failed for a mechanism (by target). Endpoint: https://mcp.nullary.ai/mcp
- search_failed_replications - Findings that failed to replicate. Endpoint: https://mcp.nullary.ai/mcp
- search_safety_failures - Clinical/preclinical safety failures across modalities. Endpoint: https://mcp.nullary.ai/mcp
- search_target_history - ALL failed approaches against a target across every modality. Endpoint: https://mcp.nullary.ai/mcp
- search_indication_history - ALL failed approaches for an indication across every modality. Endpoint: https://mcp.nullary.ai/mcp
- search_pathogen_history - Vaccine + antimicrobial + antibody failures for a pathogen. Endpoint: https://mcp.nullary.ai/mcp
- get_compound - A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources. Endpoint: https://mcp.nullary.ai/mcp
- get_finding_provenance - Full provenance + detail for a single finding by id. Endpoint: https://mcp.nullary.ai/mcp
- get_target_landscape - Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533). Endpoint: https://mcp.nullary.ai/mcp
- list_top_targets - Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other). Endpoint: https://mcp.nullary.ai/mcp
- list_models - Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC. Endpoint: https://mcp.nullary.ai/mcp
- get_model_card - Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533). Endpoint: https://mcp.nullary.ai/mcp
- get_coverage - Per-modality and per-source coverage stats (honest Phase-1 numbers). Endpoint: https://mcp.nullary.ai/mcp

## Resources
Not captured

## Prompts
Not captured

## Metadata
- Owner: ai.nullary
- Version: 1.0.1
- Runtime: Streamable Http
- Transports: HTTP
- License: Not captured
- Language: Not captured
- Stars: Not captured
- Updated: May 25, 2026
- Source: https://registry.modelcontextprotocol.io